Nature Communications (Dec 2016)

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

  • Satish Khurana,
  • Sarah Schouteden,
  • Javed K. Manesia,
  • Albert Santamaria-Martínez,
  • Joerg Huelsken,
  • Adam Lacy-Hulbert,
  • Catherine M. Verfaillie

DOI
https://doi.org/10.1038/ncomms13500
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.