Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Shian Liu; Navid Paknejad; Lan Zhu; Yasuyuki Kihara; Manisha Ray; Jerold Chun; Wei Liu; Richard K. Hite; Xin-Yun Huang

doi:10.1038/s41467-022-28417-2

Nature Communications (Feb 2022)

Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Shian Liu,
Navid Paknejad,
Lan Zhu,
Yasuyuki Kihara,
Manisha Ray,
Jerold Chun,
Wei Liu,
Richard K. Hite,
Xin-Yun Huang

Affiliations

Shian Liu: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University
Navid Paknejad: Structural Biology Program, Memorial Sloan Kettering Cancer Center
Lan Zhu: School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University
Yasuyuki Kihara: Sanford Burnham Prebys Medical Discovery Institute
Manisha Ray: Sanford Burnham Prebys Medical Discovery Institute
Jerold Chun: Sanford Burnham Prebys Medical Discovery Institute
Wei Liu: School of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State University
Richard K. Hite: Structural Biology Program, Memorial Sloan Kettering Cancer Center
Xin-Yun Huang: Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University

DOI: https://doi.org/10.1038/s41467-022-28417-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Liu et al. report structures of human sphingosine 1-phosphate (S1P) receptor 1 (S1P1) in complex with Gi and S1P or the multiple sclerosis (MS) drug Siponimod, as well as human lysophosphatidic acid (LPA) receptor 1 (LPA1) in complex with Gi and LPA, revealing distinct conformations of the lysophospholipids interacting with their cognate GPCRs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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