LIG4 mediates Wnt signalling-induced radioresistance

Sohee Jun; Youn-Sang Jung; Han Na Suh; Wenqi Wang; Moon Jong Kim; Young Sun Oh; Esther M. Lien; Xi Shen; Yoshihisa Matsumoto; Pierre D. McCrea; Lei Li; Junjie Chen; Jae-Il Park

doi:10.1038/ncomms10994

Nature Communications (Mar 2016)

LIG4 mediates Wnt signalling-induced radioresistance

Sohee Jun,
Youn-Sang Jung,
Han Na Suh,
Wenqi Wang,
Moon Jong Kim,
Young Sun Oh,
Esther M. Lien,
Xi Shen,
Yoshihisa Matsumoto,
Pierre D. McCrea,
Lei Li,
Junjie Chen,
Jae-Il Park

Affiliations

Sohee Jun: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Youn-Sang Jung: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Han Na Suh: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Wenqi Wang: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Moon Jong Kim: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Young Sun Oh: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Esther M. Lien: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Xi Shen: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Yoshihisa Matsumoto: Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology
Pierre D. McCrea: Department of Molecular Genetics, The University of Texas MD Anderson Cancer Center
Lei Li: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Junjie Chen: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
Jae-Il Park: Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms10994
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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