Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner

Nuria de Zavalia; Konrad Schoettner; Jory A. Goldsmith; Pavel Solis; Sarah Ferraro; Gabrielle Parent; Shimon Amir

doi:10.1038/s42003-021-02715-9

Communications Biology (Oct 2021)

Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner

Nuria de Zavalia,
Konrad Schoettner,
Jory A. Goldsmith,
Pavel Solis,
Sarah Ferraro,
Gabrielle Parent,
Shimon Amir

Affiliations

Nuria de Zavalia: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Konrad Schoettner: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Jory A. Goldsmith: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Pavel Solis: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Sarah Ferraro: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Gabrielle Parent: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University
Shimon Amir: Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University

DOI: https://doi.org/10.1038/s42003-021-02715-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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In order to examine the role of the circadian clock driver Brain and Muscle ARNT-Like 1 (Bmal1) in alcohol consumption, de Zavalia et al assess the effects of (Bmal1) deletion in the mouse striatum on alcohol drinking behavior. They show that striatal Bmal1 and downstream effects on Period Circadian Regulator 2 (Per2) play a sex-dependent role on alcohol consumption propensity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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