Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

Abstract

The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apoptosis.