Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

Jiao Zepeng; Zhang Bin; Li Chunya; Kuang Weicong; Zhang Jingxian; Xiong Yongqiang; Tan Shaozao; Cai Xiang; Huang Langhuan

doi:10.1515/ntrev-2018-0029

Nanotechnology Reviews (Aug 2018)

Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

Jiao Zepeng,
Zhang Bin,
Li Chunya,
Kuang Weicong,
Zhang Jingxian,
Xiong Yongqiang,
Tan Shaozao,
Cai Xiang,
Huang Langhuan

Affiliations

Jiao Zepeng: Analysis and Test Center, Jinan University, Guangzhou 510632, P.R. China
Zhang Bin: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China
Li Chunya: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China
Kuang Weicong: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China
Zhang Jingxian: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China
Xiong Yongqiang: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China
Tan Shaozao: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China
Cai Xiang: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, P.R. China
Huang Langhuan: Guangdong Engineering and Technology R&D Center of Graphene or Its Like Materials and Products, Department of Chemistry, Jinan University, Guangzhou 510632, P.R. China

DOI: https://doi.org/10.1515/ntrev-2018-0029
Journal volume & issue: Vol. 7, no. 4
pp. 291 – 301

Abstract

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A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

Published in Nanotechnology Reviews

ISSN: 2191-9089 (Print); 2191-9097 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Technology: Chemical technology; Science: Chemistry: Physical and theoretical chemistry
Website: https://www.degruyter.com/view/j/ntrev

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