Nature Communications (Sep 2019)

Discovering genetic interactions bridging pathways in genome-wide association studies

  • Gang Fang,
  • Wen Wang,
  • Vanja Paunic,
  • Hamed Heydari,
  • Michael Costanzo,
  • Xiaoye Liu,
  • Xiaotong Liu,
  • Benjamin VanderSluis,
  • Benjamin Oately,
  • Michael Steinbach,
  • Brian Van Ness,
  • Eric E. Schadt,
  • Nathan D. Pankratz,
  • Charles Boone,
  • Vipin Kumar,
  • Chad L. Myers

DOI
https://doi.org/10.1038/s41467-019-12131-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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Genetic interactions may contribute to phenotypic traits but are challenging to decipher. Here, the authors develop BridGE, a computational approach for identifying pathways connected by genetic interactions from GWAS data.