In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review

Robert H. Guirguis; Leonard P. Tan; Rebecca M. Hicks; Aniqa Hasan; Tina D. Duong; Xia Hu; Jordan Y. S. Hng; Mohammad H. Hadi; Henry C. Owuama; Tamara Matthyssen; Michael McCullough; Federica Canfora; Rita Paolini; Antonio Celentano

doi:10.3390/biom13060973

Biomolecules (Jun 2023)

In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review

Robert H. Guirguis,
Leonard P. Tan,
Rebecca M. Hicks,
Aniqa Hasan,
Tina D. Duong,
Xia Hu,
Jordan Y. S. Hng,
Mohammad H. Hadi,
Henry C. Owuama,
Tamara Matthyssen,
Michael McCullough,
Federica Canfora,
Rita Paolini,
Antonio Celentano

Affiliations

Robert H. Guirguis: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Leonard P. Tan: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Rebecca M. Hicks: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Aniqa Hasan: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Tina D. Duong: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Xia Hu: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Jordan Y. S. Hng: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Mohammad H. Hadi: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Henry C. Owuama: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Tamara Matthyssen: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Michael McCullough: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Federica Canfora: Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Naples, Italy
Rita Paolini: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia
Antonio Celentano: Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia

DOI: https://doi.org/10.3390/biom13060973
Journal volume & issue: Vol. 13, no. 6
p. 973

Abstract

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Background: Invasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear. Methods: In March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of Science were screened to identify eligible in vitro studies investigating the effects of antiresorptive and antiangiogenic compounds on orally derived cells. Results: Fifty-nine articles met the inclusion criteria. Bisphosphonates were used in 57 studies, denosumab in two, and sunitinib and bevacizumab in one. Zoledronate was the most commonly used nitrogen-containing bisphosphonate. The only non-nitrogen-containing bisphosphonate studied was clodronate. The most frequently tested tissues were gingival fibroblasts, oral keratinocytes, and alveolar osteoblasts. These drugs caused a decrease in cell proliferation, viability, and migration. Conclusions: Antiresorptive and antiangiogenic drugs displayed cytotoxic effects in a dose and time-dependent manner. Additional research is required to further elucidate the pathways of MRONJ.

Published in Biomolecules

ISSN: 2218-273X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: https://www.mdpi.com/journal/biomolecules

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