Biomedicines (May 2022)

Microbial Resistance to Antibiotics and Effective Antibiotherapy

  • Adriana Aurelia Chiș,
  • Luca Liviu Rus,
  • Claudiu Morgovan,
  • Anca Maria Arseniu,
  • Adina Frum,
  • Andreea Loredana Vonica-Țincu,
  • Felicia Gabriela Gligor,
  • Maria Lucia Mureșan,
  • Carmen Maximiliana Dobrea

DOI
https://doi.org/10.3390/biomedicines10051121
Journal volume & issue
Vol. 10, no. 5
p. 1121

Abstract

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Currently, the efficacy of antibiotics is severely affected by the emergence of the antimicrobial resistance phenomenon, leading to increased morbidity and mortality worldwide. Multidrug-resistant pathogens are found not only in hospital settings, but also in the community, and are considered one of the biggest public health concerns. The main mechanisms by which bacteria develop resistance to antibiotics include changes in the drug target, prevention of entering the cell, elimination through efflux pumps or inactivation of drugs. A better understanding and prediction of resistance patterns of a pathogen will lead to a better selection of active antibiotics for the treatment of multidrug-resistant infections.

Keywords