Dynamic regulation and key roles of ribonucleic acid methylation

Jia Zou; Jia Zou; Hui Liu; Hui Liu; Wei Tan; Yi-qi Chen; Yi-qi Chen; Jing Dong; Jing Dong; Shu-yuan Bai; Shu-yuan Bai; Zhao-xia Wu; Yan Zeng; Yan Zeng; Yan Zeng

doi:10.3389/fncel.2022.1058083

Frontiers in Cellular Neuroscience (Dec 2022)

Dynamic regulation and key roles of ribonucleic acid methylation

Jia Zou,
Jia Zou,
Hui Liu,
Hui Liu,
Wei Tan,
Yi-qi Chen,
Yi-qi Chen,
Jing Dong,
Jing Dong,
Shu-yuan Bai,
Shu-yuan Bai,
Zhao-xia Wu,
Yan Zeng,
Yan Zeng,
Yan Zeng

Affiliations

Jia Zou: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Jia Zou: Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Hui Liu: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Hui Liu: Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Wei Tan: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Yi-qi Chen: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Yi-qi Chen: Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Jing Dong: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Jing Dong: Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Shu-yuan Bai: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Shu-yuan Bai: Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Zhao-xia Wu: Community Health Service Center, Wuchang Hospital, Wuhan, China
Yan Zeng: Community Health Service Center, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China
Yan Zeng: Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Yan Zeng: School of Public Health, Wuhan University of Science and Technology, Wuhan, China

DOI: https://doi.org/10.3389/fncel.2022.1058083
Journal volume & issue: Vol. 16

Abstract

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Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs). Dysregulation of RNA methylation causes many developmental diseases through various mechanisms mediated by N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), 5-hydroxymethylcytosine (hm5C), and pseudouridine (Ψ). The emerging tools of RNA methylation can be used as diagnostic, preventive, and therapeutic markers. Here, we review the accumulated discoveries to date regarding the biological function and dynamic regulation of RNA methylation/modification, as well as the most popularly used techniques applied for profiling RNA epitranscriptome, to provide new ideas for growth and development.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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Abstract

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