Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization

Reza Talaie; Pooya Torkian; Alexander Clayton; Stephanie Wallace; Hoiwan Cheung; Majid Chalian; Jafar Golzarian

doi:10.3390/diagnostics12061403

Diagnostics (Jun 2022)

Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization

Reza Talaie,
Pooya Torkian,
Alexander Clayton,
Stephanie Wallace,
Hoiwan Cheung,
Majid Chalian,
Jafar Golzarian

Affiliations

Reza Talaie: Vascular and Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Pooya Torkian: Vascular and Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Alexander Clayton: Vascular and Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Stephanie Wallace: Vascular and Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA
Hoiwan Cheung: Department of Radiology, Division Musculoskeletal Imaging and Intervention, University of Washington, Seattle, WA 98195, USA
Majid Chalian: Department of Radiology, Division Musculoskeletal Imaging and Intervention, University of Washington, Seattle, WA 98195, USA
Jafar Golzarian: Vascular and Interventional Radiology, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, USA

DOI: https://doi.org/10.3390/diagnostics12061403
Journal volume & issue: Vol. 12, no. 6
p. 1403

Abstract

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Osteoarthritis (OA) is the major cause of disability, affecting over 30 million US adults. Continued research into the role of neovascularization and inflammation related to osteoarthritis in large-animal models and human clinical trials is paramount. Recent literature on the pathogenetic model of OA has refocused on low-level inflammation, resulting in joint remodeling. As a result, this has redirected osteoarthritis research toward limiting or treating joint changes associated with persistent synovitis. The overall goal of this review is to better understand the cellular and tissue-specific mechanisms of inflammation in relation to a novel OA treatment modality, Genicular Artery Embolization (GAE). This article also assesses the utility and mechanism of periarticular neovascular embolization for the treatment of OA with a particular emphasis on the balance between pro-angiogenic and anti-angiogenic cytokines, inflammatory biomarkers, and imaging changes.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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