Risk factors for weaning failure in critical trauma patients with non-cardiac surgery

Abstract

Objective To analyze the risk factors of weaning failure in posttraumatic critical patients with non-cardiac surgery. Methods A total of 306 patients with non-cardiac surgery who had mechanical ventilation more than 24 h after surgery, from January 2019 to December 2020, were included in this study. The clinical baseline characteristics, laboratory results, intraoperative and postoperative data of enrolled patients were retrospectively analyzed. These patients were divided into two groups: weaning success group (n=222) and weaning failure group (n=84). Risk factors for weaning failure in posttraumatic critical patients with non- cardiac surgery were determined by multivariate logistic regression analysis. Results Offline failure occurred in 84 out of 306 (27.4%) patients. After elimination of confounding factors by univariate analysis, multivariate logistic regression analysis showed that age(OR=1.835, 95%CI: 1.623~2.012, P=0.002), respiratory frequency(OR=1.860, 95%CI: 1.702~1.943, P=0.001), change rate of BNP(OR=3.366, 95%CI: 1.063~ 7.887, P=0.000) and myocardial injury after non-cardiac surgery(OR=4.237, 95%CI: 1.023~16.914, P=0.001) were the independent risk factors of weaning failure in post-traumatic critical patients with non-cardiac surgery. Conclusion Age, respiratory frequency, myocardial injury after non-cardiac surgery (MINS), and increased change rate of BNP are independent risk factors of weaning failure in post-traumatic critical patients with non-cardiac surgery.

Keywords

• trauma
• non-cardiac surgery
• weaning
• risk factors