Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans

Wenjun Yang; Longman Li; Xiuming Feng; Hong Cheng; Xiaoting Ge; Yu Bao; Lulu Huang; Fei Wang; Chaoqun Liu; Xing Chen; Zengnan Mo; Xiaobo Yang

doi:10.1038/s42003-022-03351-7

Communications Biology (May 2022)

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans

Wenjun Yang,
Longman Li,
Xiuming Feng,
Hong Cheng,
Xiaoting Ge,
Yu Bao,
Lulu Huang,
Fei Wang,
Chaoqun Liu,
Xing Chen,
Zengnan Mo,
Xiaobo Yang

Affiliations

Wenjun Yang: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Longman Li: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Xiuming Feng: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Hong Cheng: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Xiaoting Ge: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Yu Bao: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Lulu Huang: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Fei Wang: Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University
Chaoqun Liu: Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University
Xing Chen: School of Public Health, Guangxi Medical University
Zengnan Mo: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University
Xiaobo Yang: Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University

DOI: https://doi.org/10.1038/s42003-022-03351-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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A genome-wide association study in a Chinese population identifies SNPs associated with serum copper levels. Mendelian randomization analysis reveals causal effects on multiple human phenotypes in East Asian and European populations.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal