Nature Communications (Jul 2019)

Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification

  • José M. Santos-Pereira,
  • Lourdes Gallardo-Fuentes,
  • Ana Neto,
  • Rafael D. Acemel,
  • Juan J. Tena

DOI
https://doi.org/10.1038/s41467-019-11121-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promoting chromatin opening at epidermal gene enhancers.