Nature Communications (Jun 2021)

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

  • Caillan Crowe-McAuliffe,
  • Victoriia Murina,
  • Kathryn Jane Turnbull,
  • Marje Kasari,
  • Merianne Mohamad,
  • Christine Polte,
  • Hiraku Takada,
  • Karolis Vaitkevicius,
  • Jörgen Johansson,
  • Zoya Ignatova,
  • Gemma C. Atkinson,
  • Alex J. O’Neill,
  • Vasili Hauryliuk,
  • Daniel N. Wilson

DOI
https://doi.org/10.1038/s41467-021-23753-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.