PERSIST platform provides programmable RNA regulation using CRISPR endoRNases

Breanna DiAndreth; Noreen Wauford; Eileen Hu; Sebastian Palacios; Ron Weiss

doi:10.1038/s41467-022-30172-3

Nature Communications (May 2022)

PERSIST platform provides programmable RNA regulation using CRISPR endoRNases

Breanna DiAndreth,
Noreen Wauford,
Eileen Hu,
Sebastian Palacios,
Ron Weiss

Affiliations

Breanna DiAndreth: Department of Biological Engineering, Massachusetts Institute of Technology
Noreen Wauford: Department of Biological Engineering, Massachusetts Institute of Technology
Eileen Hu: Department of Biological Engineering, Massachusetts Institute of Technology
Sebastian Palacios: Department of Biological Engineering, Massachusetts Institute of Technology
Ron Weiss: Department of Biological Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-30172-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Gene circuits must resist epigenetic silencing for reliable therapeutic applications. Here the authors develop an RNA-level regulation platform using CRISPR endoRNases that is modular, scalable, and more stable than traditional transcriptional versions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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