Quercetin attenuated the Benzene-induced hemato- and hepatotoxicity in mice

Abstract

The protective effects of Quercetin (QCN) on Benzene (BNZ)-induced hemato- and hepatotoxicy were investigated. To reach this goal, 36 adult male mice were divided into 6 groups (n = 6). The control group was not exposed to BNZ, while animals in BNZ group were exposed to BNZ (30 ppm) and the animals of QCN group were received QCN (50 mg/kg, orally), the fourth, fifth and sixth groups were exposed to 30 ppm BNZ and received 10, 50 and 100 mg/kg QCN one h before the BNZ exposure, for 28 days. The day after the last exposure following anesthesia and the blood collection, the liver and femur tissues were collected. The bone marrow samples were extracted and subjected to micronucleus assay. The blood samples were processed for hematological and biochemical analyses. Histopathological examinations were performed on the liver samples. QCN reduced significantly (p < 0.05) the BNZ-elevated hepatic enzymes and ameliorated the BNZ-induced WBC and RBC reduction. The BNZ-elevated micronucleus percentage both in the bone marrow and peripheral blood was remarkably declined in the QCN-received groups. QCN improved the BNZ-induced histopathological changes and oxidative status in the liver and serum. Our results suggest that QCN could be a protective supplement to reduce the BNZ-induced hemato- and hepatotoxicities.

Keywords

• Hematotoxicity
• Hepatotoxicity
• Micronucleus
• Oxidative status