Study of Drug Resistance in Klebsiella Isolates in A Tertiary Care Centre

Abstract

Context: Members of genus klebsiella cause various infections like urinary tract infection, septicemia, lower respiratory tract infection. Klebsiella has become resistant to numerous antibiotics. Aims: The study was attempted to evaluate antimicrobial susceptibility pattern among klebsiella isolates. Settings and design: Klebsiella isolates from samples of patients with various infections admitted to a tertiary care hospital. Material and Methods: Klebsiella isolates from different clinical specimens were subjected to antibiotic susceptibility testing. Production of extended spectrum β-lactamase, AmpC β-lactamase and carbapenemase was tested. Results: One hundred and three klebsiella strains were studied, of which 89 were Klebsiella pneumoniae and 14 were Klebsiella oxytoca. Twenty three strains were ESBL, four AmpC and 12 metallo-β-lactamase producers. Conclusion: High drug resistance and β-lactamase production was observed in klebsiella isolates.

Keywords

• klebsiella
• drug resistance
• β-lactamase production