LIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGY

Abstract

Antisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeutic applications.Methods of ASO chemical modification; advantages and disadvantages of different ways of ASO delivery into the cells; developments state of ASO-drugs for therapy of lipid metabolism disturbances; data from clinical trials of these drugs are described.

Keywords

• антисенс-терапия
• антисмысловые олигонуклеотиды
• нарушение липидного обмена
• сердечно-сосудистые заболевания