Nature Communications (Jan 2017)
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
- Cara Lunn Shirai,
- Brian S. White,
- Manorama Tripathi,
- Roberto Tapia,
- James N. Ley,
- Matthew Ndonwi,
- Sanghyun Kim,
- Jin Shao,
- Alexa Carver,
- Borja Saez,
- Robert S. Fulton,
- Catrina Fronick,
- Michelle O’Laughlin,
- Chandraiah Lagisetti,
- Thomas R. Webb,
- Timothy A. Graubert,
- Matthew J. Walter
Affiliations
- Cara Lunn Shirai
- Division of Oncology, Washington University School of Medicine
- Brian S. White
- Division of Oncology, Washington University School of Medicine
- Manorama Tripathi
- Division of Oncology, Washington University School of Medicine
- Roberto Tapia
- Division of Oncology, Washington University School of Medicine
- James N. Ley
- Division of Oncology, Washington University School of Medicine
- Matthew Ndonwi
- Division of Oncology, Washington University School of Medicine
- Sanghyun Kim
- Division of Oncology, Washington University School of Medicine
- Jin Shao
- Division of Oncology, Washington University School of Medicine
- Alexa Carver
- Division of Oncology, Washington University School of Medicine
- Borja Saez
- Massachusetts General Hospital Cancer Center
- Robert S. Fulton
- McDonnell Genome Institute, Washington University
- Catrina Fronick
- McDonnell Genome Institute, Washington University
- Michelle O’Laughlin
- McDonnell Genome Institute, Washington University
- Chandraiah Lagisetti
- Bioscience Division, SRI International
- Thomas R. Webb
- Bioscience Division, SRI International
- Timothy A. Graubert
- Massachusetts General Hospital Cancer Center
- Matthew J. Walter
- Division of Oncology, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms14060
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Spliceosome mutations occur in approximately 50% of patients with myelodysplastic syndromes. Here, the authors show that tumour cells harbouring theS34F mutation in the U2AFspliceosome gene is sensitive to compounds that further perturb the spliceosome.
