ALTERNATIVE APPROACHES TO MEDICAL ABORTION

Abstract

Medical abortion involving various pharmacological agents has demonstrated high levels of complete uterine evacuation. Alternative approaches involving letrozole, mifepristone, methotrexate used synergically with misoprostol are non-invasive elective methods of achieving complete abortion. Abortion induced by mifepristone, letrozole and misoprostol results in complete evacuation in 98% of the cases.The synergic effect of mifepristone and misoprostol achieves 98.2% effectiveness. Medical management of abortion with letrozole and misoprostol has 97.8% complete expulsion. Current reports of surgical termination of pregnancy reveal 97% effectiveness. Letrozole destabilizes the dominant position of mifepristone but the reports of its non-significant prevalence regarding complete abortion should be verified by a larger number of studies. Medical abortion is non-inferior in its effectiveness to surgical abortion and is unambiguously likely to become in the future the principal recommendation for termination of early pregnancy.

Keywords

• letrozole
• mifepristone
• methotrexate
• misoprostol
• non-invasive
• abortion