Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat

Abstract

Background: SIRT1 and FGF21 are known to regulate glucose metabolism and moderate diabetes complications. Sargassum oligocystum extract has therapeutic characteristics. This study aimed to evaluate the effects of hydroalcoholic extract of sargassum oligocystum on serum levels of SIRT1 and FGF21in diabetic rats. Materials and methods: In this experimental study, 48 male Wistar rats were randomly assigned into six groups: the non-diabetic control, the diabetic control, the diabetic treated with 150mg/kg of the extract, the diabetic treated with 300mg/kg of extract, the diabetic treated with 450mg/kg of the extract and the diabetic treated with 100mg/kg of Metformin. After 30 days of treatment, serum levels of SIRT1 and FGF21 of rats were measured. The data was analyzed in SPSS software version 22. Results: The extract of sargassum at the dose of 450mg/kg significantly reduced the SIRT1 serum level, but no changes were observed in the serum level of FGF21 and insulin at any of the doses. Moreover, serum glucose and insulin resistance were decreased at the doses of 300mg/kg of the extract. Conclusion: The results of this study suggest that the algae extract did not significantly change SIRT1 and FGF21 levels in order to regulate the glucose metabolism.

Keywords

• Diabetes
• Sargassum oligocystum
• SIRT1
• FGF21