⁹⁹Tc-MDP inhibits corneal neovascularization induced by alkali burn in rats

Abstract

AIM: To evaluate the effect of inhibition of 99Tc-MDP on experimental corneal neovascularization in rats.METHODS: Chemical cauterization of the cornea was performed by touching alkali. Twenty-four healthy SD rats were divided randomly into two equal groups: experimental group underwent i.p. injection of 99Tc-MDP everyday until 14th day after alkali burn. Control group underwent i.p. injection of normal saline as control. Rats were examined for detection of the first signs of neovascularization. 21 days later, lengths of neovascular and total corneal neovascularization area were assessed.RESULTS: The time of neovascularization in experimental group was 6.25±1.93 days, the control group was 5.83±1.86 days, and there was no statistically significant difference(P=0.30). The lengths of neovascular were 1.74±0.33mm and 2.82±0.25mm in two groups and the difference was statistically significant. The total neovascularization area was 17.3±3.26mm2, 24.8±5.10mm2 respectively and the difference between the two groups was statistically significant(PCONCLUSION: 99Tc-MDP has a significant effect on inhibition of alkali burn-induced corneal neovascularization.

Keywords

• ⁹⁹Tc-MDP
• corneal neovascularization
• rat
• inhibition