Nature Communications (Nov 2017)

KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression

  • Hongmei Zhao,
  • Xiaoshuang Wang,
  • Ping Yi,
  • Yanmin Si,
  • Puwen Tan,
  • Jinrong He,
  • Shan Yu,
  • Yue Ren,
  • Yanni Ma,
  • Junwu Zhang,
  • Dong Wang,
  • Fang Wang,
  • Jia Yu

DOI
https://doi.org/10.1038/s41467-017-01425-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 19

Abstract

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RNA-binding proteins (RBPs) regulate RNA activity and are implicated in haematopoietic malignancies, but their role in myeloid cell specification is unclear. Here, the authors show a role for the RBP KSRP in promoting granulocyte fate over monocyte fate through the biogenesis of miR-129 and a decrease in RUNX1.