Nature Communications (May 2020)

Mutational signatures are jointly shaped by DNA damage and repair

  • Nadezda V. Volkova,
  • Bettina Meier,
  • Víctor González-Huici,
  • Simone Bertolini,
  • Santiago Gonzalez,
  • Harald Vöhringer,
  • Federico Abascal,
  • Iñigo Martincorena,
  • Peter J. Campbell,
  • Anton Gartner,
  • Moritz Gerstung

DOI
https://doi.org/10.1038/s41467-020-15912-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Recent research has shown that mutational signatures reflective of the history of a cancer can be detected in a cancer genome. Here, using whole genome sequencing of DNA repair deficient and proficient nematodes exposed to genotoxins, the authors show that these mutational signatures reflect both the initial DNA damage that was inflicted and the repair processes that ensue.