Comparative characteristics of enzymatic antioxidant protection in patients with mild cognitive decline and late-onset depression. Is a therapeutic correction possible?

Abstract

Free radical processes, the degree of their intensification are one of the main pathogenetic factors in the development of many diseases in old age. The purpose of this study was to identify the severity of OS in patients with mild cognitive decline (presumably Alzheimer’s disease), with mild cognitive decline in vascular etiology, in persons suffering from a depressive disorder compared to a control group of the same age. A special vulnerability of the glutathione system was found in patients of all the examined groups, in particular, in people with depression, in comparison with healthy elderly people. A decrease in the activity of glutathione peroxidase, significantly more pronounced in the examined patients with late depression, was revealed. The data obtained agree with the IDEA existing in modern science on the role of OS as a key element in the pathogenesis of depressive states.

Keywords

• мягкое когнитивное снижение
• депрессия позднего возраста
• окислительный стресс
• актиоксидантная защита
• глутатионпероксидаза
• ницерголин
• mild cognitive decline
• late age depression
• oxidative stress
• antioxidant protection
• glutathione peroxidase
• nicergoline