STUDY OF STABILITY OF CELL CARRIERS AND CELLULAR FORMS OF VINKRISTIN AND VINBLASTIN IN STORAGE

Abstract

Employees of the department of pharmaceutical chemistry and phar-maceutical technology received modified forms of terpene-indole alkaloids (TIA) - vincristine (VCR) and vinblastine (VBL) known in the therapy of oncological diseases by incorporating them into erythrocyte carriers (EN). This method of modification allows solving simultaneously the problems of directional transport of effective antitumor drugs and reducing the frequency and strength of side effects, and, consequently, increasing the patient's compliance to the prescribed treatment. In this paper, stability and shelf life studies of encapsulated TIAs in EN have been carried out. It was found that keeping TIA encapsulated erythrocyte form at +4 °С for 7 days is the optimal condition for storage of TIA preparations without significant reduction of the therapeutic dose (not less than 95% of the encapsulated amount).

Keywords

• vincristine
• vinblastine
• directed transport of medicinal substances
• erythrocyte carriers
• degree of hemolysis of erythrocytes