Changes in angiogenesis markers during neoadjuvant treatment for locally advanced breast cancer

Abstract

The impact of various neoadjuvant treatment regimens on the level of enzyme immunoassay-determined angiogenic markers of endothelial growth factor and its type 2 receptor in tumor cytosol and serum was assessed in 30 patients with locally advanced breast cancer (BC). The findings suggest the promises for studies of neoangiogenesis factors mainly in tumor tissue for their possible use as prognostic biological markers in patients with BC.

Keywords

• фактор роста эндотелия сосудов
• рецептор фактора роста эндотелия сосудов 2-го типа
• ангиогенез
• рак молочной железы
• неоадъювантная терапия