Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

Aitor Almanza; Katarzyna Mnich; Arnaud Blomme; Claire M. Robinson; Giovanny Rodriguez-Blanco; Sylwia Kierszniowska; Eoghan P. McGrath; Matthieu Le Gallo; Eleftherios Pilalis; Johannes V. Swinnen; Aristotelis Chatziioannou; Eric Chevet; Adrienne M. Gorman; Afshin Samali

doi:10.1038/s41467-022-30159-0

Nature Communications (May 2022)

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

Aitor Almanza,
Katarzyna Mnich,
Arnaud Blomme,
Claire M. Robinson,
Giovanny Rodriguez-Blanco,
Sylwia Kierszniowska,
Eoghan P. McGrath,
Matthieu Le Gallo,
Eleftherios Pilalis,
Johannes V. Swinnen,
Aristotelis Chatziioannou,
Eric Chevet,
Adrienne M. Gorman,
Afshin Samali

Affiliations

Aitor Almanza: Apoptosis Research Centre, National University of Ireland
Katarzyna Mnich: Apoptosis Research Centre, National University of Ireland
Arnaud Blomme: CRUK Beatson Institute
Claire M. Robinson: Apoptosis Research Centre, National University of Ireland
Giovanny Rodriguez-Blanco: CRUK Beatson Institute
Sylwia Kierszniowska: metaSysX GmbH
Eoghan P. McGrath: Apoptosis Research Centre, National University of Ireland
Matthieu Le Gallo: Inserm U1242, University of Rennes
Eleftherios Pilalis: e-NIOS Applications PC
Johannes V. Swinnen: Department of Oncology, Laboratory of Lipid Metabolism and Cancer, KU Leuven Cancer Institute
Aristotelis Chatziioannou: e-NIOS Applications PC
Eric Chevet: Inserm U1242, University of Rennes
Adrienne M. Gorman: Apoptosis Research Centre, National University of Ireland
Afshin Samali: Apoptosis Research Centre, National University of Ireland

DOI: https://doi.org/10.1038/s41467-022-30159-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid metabolism in cancer cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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