Communications Biology (Feb 2021)

ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection

  • Shousheng Ni,
  • Yang Zhou,
  • Lili Song,
  • Yan Chen,
  • Xia Wang,
  • Xiaoyuan Du,
  • Shicui Zhang

DOI
https://doi.org/10.1038/s42003-021-01777-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Ni et al. show that RNA-binding protein ELAVL1a is abundantly stored in the eggs and embryos of zebrafish, serving as a first-line innate immune player. They find that ELAVL1a recognizes molecular patterns of bacteria to inhibit bacterial growth. This study suggests that ELAVL1a is a maternal immune factor protecting zebrafish embryos from bacterial infection.