Diabetes, Metabolic Syndrome and Obesity (May 2020)
Changes in Serum Nesfatin-1 After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Nonalcoholic Fatty Liver Disease
Abstract
Keyu Yang, Xiaowei Zhang, Yong Zhou, Fu Chen, Mingyang Shen, Yong Wang Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaCorrespondence: Yong WangDepartment of General Surgery, Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan East Road, Huanggu District, Shenyang City, Liaoning Province 110032, People’s Republic of ChinaTel +8618940259733Email [email protected]: Nonalcoholic fatty liver disease (NAFLD) is a serious and widespread disease worldwide. Bariatric surgery is one of the treatments for NAFLD. Nesfatin-1 is located in the brain, periphery and plasma. We studied the relationship between nesfatin-1 changes after laparoscopic sleeve gastrectomy (LSG) and NAFLD remission.Methods: A total of 29 patients participated in the study, which collected clinical information on the patients and indicators of liver function, hepatic steatosis score and nesfatin-1 level before and after LSG.Results: The average BMI of the patients before surgery was 42.63± 8.91 kg/m2, and the average BMI was 28.54± 5.63 kg/m2 one year after surgery (p < 0.05). One year after LSG, the total weight loss percentage (TWL%) was 32.11± 7.10%. The mean value of nesfatin-1 before surgery was 3.04± 0.81 ng/mL, and the mean value of nesfatin-1 was 5.52± 1.55 ng/mL at one year after surgery (p < 0.05). The average preoperative hepatic steatosis index (HSI) score of the patients was 52.55± 9.17, and the average postoperative HSI score was 38.84± 5.82 (p < 0.05). Before LSG (p < 0.05, r= − 0.81) and 1 year after surgery (p < 0.05, r = − 0.58), HSI and nesfatin-1 were significantly negatively correlated. Percentage of increased nesfatin-1 and percentage of decreased HSI showed positive correlation after LSG.Conclusion: There was a negative correlation between HSI and nesfatin-1 before and after LSG, which may suggest that nesfatin-1 plays a role in NAFLD.Keywords: nesfatin-1, NAFLD, bariatric surgery, LSG
