Nature Communications (Nov 2018)
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
- David Novo,
- Nikki Heath,
- Louise Mitchell,
- Giuseppina Caligiuri,
- Amanda MacFarlane,
- Dide Reijmer,
- Laura Charlton,
- John Knight,
- Monika Calka,
- Ewan McGhee,
- Emmanuel Dornier,
- David Sumpton,
- Susan Mason,
- Arnaud Echard,
- Kerstin Klinkert,
- Judith Secklehner,
- Flore Kruiswijk,
- Karen Vousden,
- Iain R. Macpherson,
- Karen Blyth,
- Peter Bailey,
- Huabing Yin,
- Leo M. Carlin,
- Jennifer Morton,
- Sara Zanivan,
- Jim C. Norman
Affiliations
- David Novo
- Beatson Institute for Cancer Research
- Nikki Heath
- Beatson Institute for Cancer Research
- Louise Mitchell
- Beatson Institute for Cancer Research
- Giuseppina Caligiuri
- Institute of Cancer Sciences, University of Glasgow
- Amanda MacFarlane
- Beatson Institute for Cancer Research
- Dide Reijmer
- Beatson Institute for Cancer Research
- Laura Charlton
- School of Engineering, University of Glasgow
- John Knight
- Beatson Institute for Cancer Research
- Monika Calka
- Institute of Cancer Sciences, University of Glasgow
- Ewan McGhee
- Beatson Institute for Cancer Research
- Emmanuel Dornier
- Beatson Institute for Cancer Research
- David Sumpton
- Beatson Institute for Cancer Research
- Susan Mason
- Beatson Institute for Cancer Research
- Arnaud Echard
- Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur
- Kerstin Klinkert
- Membrane Traffic and Cell Division Lab, Cell Biology and Infection Department, Institut Pasteur
- Judith Secklehner
- Beatson Institute for Cancer Research
- Flore Kruiswijk
- Beatson Institute for Cancer Research
- Karen Vousden
- Beatson Institute for Cancer Research
- Iain R. Macpherson
- Beatson Institute for Cancer Research
- Karen Blyth
- Beatson Institute for Cancer Research
- Peter Bailey
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Huabing Yin
- School of Engineering, University of Glasgow
- Leo M. Carlin
- Beatson Institute for Cancer Research
- Jennifer Morton
- Beatson Institute for Cancer Research
- Sara Zanivan
- Beatson Institute for Cancer Research
- Jim C. Norman
- Beatson Institute for Cancer Research
- DOI
- https://doi.org/10.1038/s41467-018-07339-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts, whereby mutant p53-expressing cancer cells activate an exosome-mediated mechanism that influences integrin recycling in fibroblasts, thus influencing extracellular matrix remodelling to favour cancer cell invasion and migration.
