Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception

Raffaele Mazziotti; Laura Baroncelli; Nicholas Ceglia; Gabriele Chelini; Grazia Della Sala; Christophe Magnan; Debora Napoli; Elena Putignano; Davide Silingardi; Jonida Tola; Paola Tognini; J. Simon C. Arthur; Pierre Baldi; Tommaso Pizzorusso

doi:10.1038/ncomms15488

Nature Communications (May 2017)

Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception

Raffaele Mazziotti,
Laura Baroncelli,
Nicholas Ceglia,
Gabriele Chelini,
Grazia Della Sala,
Christophe Magnan,
Debora Napoli,
Elena Putignano,
Davide Silingardi,
Jonida Tola,
Paola Tognini,
J. Simon C. Arthur,
Pierre Baldi,
Tommaso Pizzorusso

Affiliations

Raffaele Mazziotti: Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA University of Florence
Laura Baroncelli: Institute of Neuroscience, National Research Council, Via Moruzzi
Nicholas Ceglia: Department of Computer Science, University of California, Irvine
Gabriele Chelini: Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA University of Florence
Grazia Della Sala: Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA University of Florence
Christophe Magnan: Department of Computer Science, University of California, Irvine
Debora Napoli: BIO@SNS lab, Scuola Normale Superiore via Moruzzi
Elena Putignano: Institute of Neuroscience, National Research Council, Via Moruzzi
Davide Silingardi: Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA University of Florence
Jonida Tola: Institute of Neuroscience, National Research Council, Via Moruzzi
Paola Tognini: BIO@SNS lab, Scuola Normale Superiore via Moruzzi
J. Simon C. Arthur: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Pierre Baldi: Department of Computer Science, University of California, Irvine
Tommaso Pizzorusso: Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA University of Florence

DOI: https://doi.org/10.1038/ncomms15488
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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miR-132/212 has been implicated in ocular dominance plasticity during the critical period. Here the authors show that miR-132/212 regulates the expression of genes involved in visual cortex maturation, and that mice lack miR-132/212 show deficits in binocular matching of orientation preferences, which leads to impaired depth perception.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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