Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment

Analiz Rodriguez; Stephen B. Tatter; Waldemar Debinski

doi:10.3390/pharmaceutics7030175

Pharmaceutics (Aug 2015)

Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment

Analiz Rodriguez,
Stephen B. Tatter,
Waldemar Debinski

Affiliations

Analiz Rodriguez: The Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University, Medical Center Boulevard, Winston Salem 27157, NC, USA
Stephen B. Tatter: The Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University, Medical Center Boulevard, Winston Salem 27157, NC, USA
Waldemar Debinski: The Brain Tumor Center of Excellence, Department of Neurosurgery, Wake Forest University, Medical Center Boulevard, Winston Salem 27157, NC, USA

DOI: https://doi.org/10.3390/pharmaceutics7030175
Journal volume & issue: Vol. 7, no. 3
pp. 175 – 187

Abstract

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The blood–brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood–brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood–brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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