Nature Communications (Dec 2022)
Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection
- Curtis Cai,
- Jerome Samir,
- Mehdi R. Pirozyan,
- Thiruni N. Adikari,
- Money Gupta,
- Preston Leung,
- Brendan Hughes,
- Willem Van der Byl,
- Simone Rizzetto,
- Auda Elthala,
- Elizabeth Keoshkerian,
- Jean-Louis Palgen,
- Timothy Peters,
- Thi H. O. Nguyen,
- Raymond Louie,
- Katherine Kedzierska,
- Silvana Gaudieri,
- Rowena A. Bull,
- Andrew R. Lloyd,
- Fabio Luciani
Affiliations
- Curtis Cai
- School of Medical Sciences, University of New South Wales
- Jerome Samir
- School of Medical Sciences, University of New South Wales
- Mehdi R. Pirozyan
- School of Medical Sciences, University of New South Wales
- Thiruni N. Adikari
- School of Medical Sciences, University of New South Wales
- Money Gupta
- School of Medical Sciences, University of New South Wales
- Preston Leung
- School of Medical Sciences, University of New South Wales
- Brendan Hughes
- School of Medical Sciences, University of New South Wales
- Willem Van der Byl
- School of Medical Sciences, University of New South Wales
- Simone Rizzetto
- School of Medical Sciences, University of New South Wales
- Auda Elthala
- Kirby Institute for Infection and Immunity, University of New South Wales
- Elizabeth Keoshkerian
- School of Medical Sciences, University of New South Wales
- Jean-Louis Palgen
- School of Medical Sciences, University of New South Wales
- Timothy Peters
- Garvan Institute for Medical Research
- Thi H. O. Nguyen
- Peter Doherty Institute, University of Melbourne
- Raymond Louie
- School of Medical Sciences, University of New South Wales
- Katherine Kedzierska
- Peter Doherty Institute, University of Melbourne
- Silvana Gaudieri
- School of Human Sciences, University of Western Australia
- Rowena A. Bull
- School of Medical Sciences, University of New South Wales
- Andrew R. Lloyd
- Kirby Institute for Infection and Immunity, University of New South Wales
- Fabio Luciani
- School of Medical Sciences, University of New South Wales
- DOI
- https://doi.org/10.1038/s41467-022-35281-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The early immune response following exposure to HCV is not fully explored. Here the authors use single cell analysis and immune profiling to relate the infection sequence and immune response to early HCV infection showing that exhausted phenotypes of T cells arise early post infection.
