Role of MIR-196a2 Gene Polymorphism in Some Hormonal and Physiological Parameters Levels in Type 2 Diabetic Patients

Abstract

The genetic analysis of the Single Nucleotide Polymorphisms, for miR- 196a2 gene by using PCR-SSCP technique that there were non-significant difference in the genotype polymorphisms between patients and control. On the other hand, the statistical analysis for the role of microRNAs genes in the hormones and physiological parameters found that the genotype pattern (A) of miR-196a2 show more effects in changes of the parameters (cortisol, testosterone, estradiol, insulin, glucagon, Fasting Blood Glucose (FBG), insulin resistance, insulin sensitivity, microalbuminuria systolic and diastolic pressure). The variation in the genotype of miR-196a2 and its effect on the physiological parameters increase the risk of CVD in type 2 diabetes patients.

Keywords

• type 2 diabetes
• microrna
• mir-196a2
• polymorphism
• sscp technique