CAR-T Therapy in Lymphoma Patients With Coexisting Cardiomyopathy or Cardiac Lymphomatous Involvement

Choon Ta Ng, MBBS; Hilda M. Gonzalez Bonilla, MD; Ian Chang, MD; M. Tun Aung, MD; Jennifer J. Gile, MD; Naveen L. Pereira, MD; Jose C. Villasboas Bisneto, MD; Patrick B. Johnston, MD; Hector R. Villarraga, MD; Martin G. Rodriguez-Porcel, MD; Grace Lin, MD; Yi Lin, MD, PhD; Joerg Herrmann, MD

JACC: Case Reports (Jun 2023)

CAR-T Therapy in Lymphoma Patients With Coexisting Cardiomyopathy or Cardiac Lymphomatous Involvement

Choon Ta Ng, MBBS,
Hilda M. Gonzalez Bonilla, MD,
Ian Chang, MD,
M. Tun Aung, MD,
Jennifer J. Gile, MD,
Naveen L. Pereira, MD,
Jose C. Villasboas Bisneto, MD,
Patrick B. Johnston, MD,
Hector R. Villarraga, MD,
Martin G. Rodriguez-Porcel, MD,
Grace Lin, MD,
Yi Lin, MD, PhD,
Joerg Herrmann, MD

Affiliations

Choon Ta Ng, MBBS: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA; Department of Cardiology, National Heart Centre Singapore
Hilda M. Gonzalez Bonilla, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
Ian Chang, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
M. Tun Aung, MD: Department of Hematology, The University of Kansas Cancer Center, Kansas City, Kansas, USA
Jennifer J. Gile, MD: Department of Hematology, Mayo Clinic Rochester, Rochester, Minnesota, USA
Naveen L. Pereira, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
Jose C. Villasboas Bisneto, MD: Department of Hematology, Mayo Clinic Rochester, Rochester, Minnesota, USA
Patrick B. Johnston, MD: Department of Hematology, Mayo Clinic Rochester, Rochester, Minnesota, USA
Hector R. Villarraga, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
Martin G. Rodriguez-Porcel, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
Grace Lin, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA
Yi Lin, MD, PhD: Department of Hematology, Mayo Clinic Rochester, Rochester, Minnesota, USA
Joerg Herrmann, MD: Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA; Address for correspondence: Dr Joerg Herrmann, Mayo Clinic Rochester, 200 First Street SW, Rochester, Minnesota 55905, USA.

Journal volume & issue: Vol. 15
p. 101840

Abstract

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Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of aggressive hematologic malignancies. However, its role in patients with lymphoma and cardiac metastasis or cardiomyopathy remains undefined due to potentially life-threatening complications such as ventricular rupture, cardiac tamponade, and circulatory failure. We present a case series of patients with lymphoma and cardiomyopathy or cardiac metastasis managed with chimeric antigen receptor T-cell therapy. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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