Sudden Onset of IgA Vasculitis Affecting Vital Organs in Adult Patients following SARS-CoV-2 Vaccines
Yunjung Choi,
Chang Hun Lee,
Kyoung Min Kim,
Wan-Hee Yoo
Affiliations
Yunjung Choi
Division of Rheumatology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju City 54907, Korea
Chang Hun Lee
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju City 54907, Korea
Kyoung Min Kim
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju City 54907, Korea
Wan-Hee Yoo
Division of Rheumatology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju City 54907, Korea
IgA vasculitis is an immune complex-mediated small-vessel vasculitis that mainly occurs in children and is characterized by palpable purpura, arthralgia, abdominal pain, and glomerulonephritis. We report three cases of new-onset IgA vasculitis involving major organs in adult patients after they received either the ChAdOx1 viral vector (Oxford/AstraZeneca) vaccine or the messenger RNA-1273 (Moderna) vaccine. These cases suggest that COVID-19 vaccines have the potential to trigger IgA vasculitis and indicate that physicians need to monitor for this possible complication.
