Journal of Epidemiology and Global Health (Jul 2023)
Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project
- Stefano Porru,
- Maria Grazia Lourdes Monaco,
- Gianluca Spiteri,
- Angela Carta,
- Gulser Caliskan,
- Concepción Violán,
- Pere Torán-Monserrat,
- Luigi Vimercati,
- Silvio Tafuri,
- Paolo Boffetta,
- Francesco Saverio Violante,
- Emma Sala,
- Emanuele Sansone,
- Fabriziomaria Gobba,
- Loretta Casolari,
- Andreas Wieser,
- Christian Janke,
- Adonina Tardon,
- Marta Maria Rodriguez-Suarez,
- Filippo Liviero,
- Maria Luisa Scapellato,
- Marco dell’Omo,
- Nicola Murgia,
- Dana Mates,
- Violeta Claudia Calota,
- Jozef Strhársky,
- Mariana Mrázová,
- Enrico Pira,
- Alessandro Godono,
- Greta Camilla Magnano,
- Corrado Negro,
- Giuseppe Verlato,
- Orchestra WP5 Working Group
Affiliations
- Stefano Porru
- Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona
- Maria Grazia Lourdes Monaco
- Occupational Medicine Unit, University Hospital of Verona
- Gianluca Spiteri
- Occupational Medicine Unit, University Hospital of Verona
- Angela Carta
- Section of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona
- Gulser Caliskan
- Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona
- Concepción Violán
- Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Unitat de Suport a la Recerca Metropolitana Nord
- Pere Torán-Monserrat
- Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Unitat de Suport a la Recerca Metropolitana Nord
- Luigi Vimercati
- Interdisciplinary Department of Medicine, University of Bari
- Silvio Tafuri
- Interdisciplinary Department of Medicine, University of Bari
- Paolo Boffetta
- Department of Medical and Surgical Sciences, University of Bologna
- Francesco Saverio Violante
- Department of Medical and Surgical Sciences, University of Bologna
- Emma Sala
- Unit of Occupational Health, Hygiene, Toxicology and Prevention, University Hospital ASST Spedali Civili
- Emanuele Sansone
- Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Unit of Occupational Health and Industrial Hygiene, University of Brescia
- Fabriziomaria Gobba
- Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia
- Loretta Casolari
- Health Surveillance Service, University Hospital of Modena
- Andreas Wieser
- Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich
- Christian Janke
- Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich
- Adonina Tardon
- University of Oviedo, Health Research Institute of Asturias (ISPA) and CIBERESP
- Marta Maria Rodriguez-Suarez
- HUCA (SESPA), University of Oviedo, and Health Research Institute of Asturias (ISPA)
- Filippo Liviero
- Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova
- Maria Luisa Scapellato
- Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova
- Marco dell’Omo
- Section of Occupational Medicine, Respiratory Diseases and Toxicology, Department of Medicine and Surgery, University of Perugia
- Nicola Murgia
- Department of Environmental and Prevention Sciences, University of Ferrara
- Dana Mates
- National Institute of Public Health
- Violeta Claudia Calota
- National Institute of Public Health
- Jozef Strhársky
- Medical Microbiology Department, Regional Authority of Public Health
- Mariana Mrázová
- Public Health Institute, St. Elizabeth University of Health and Social Work
- Enrico Pira
- Department of Public Health and Pediatrics, University of Torino
- Alessandro Godono
- Department of Public Health and Pediatrics, University of Torino
- Greta Camilla Magnano
- Department of Medical Sciences, Unit of Occupational Medicine, University of Trieste
- Corrado Negro
- Department of Medical Sciences, Unit of Occupational Medicine, University of Trieste
- Giuseppe Verlato
- Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona
- Orchestra WP5 Working Group
- DOI
- https://doi.org/10.1007/s44197-023-00139-8
- Journal volume & issue
-
Vol. 13,
no. 3
pp. 577 – 588
Abstract
Abstract Background SARS-CoV-2 breakthrough infections (BI) after vaccine booster dose are a relevant public health issue. Methods Multicentric longitudinal cohort study within the ORCHESTRA project, involving 63,516 health workers (HW) from 14 European settings. The study investigated the cumulative incidence of SARS-CoV-2 BI after booster dose and its correlation with age, sex, job title, previous infection, and time since third dose. Results 13,093 (20.6%) BI were observed. The cumulative incidence of BI was higher in women and in HW aged 130 days. Conclusions The risk of BI after booster is significantly reduced by previous infection, heterologous vaccination, and older ages. Immunosuppression is relevant for increased BI incidence. Time elapsed from booster affects BI severity, confirming the public health usefulness of booster. Further research should focus on BI trend after 4th dose and its relationship with time variables across the epidemics.
Keywords
- SARS-CoV-2
- COVID-19 breakthrough infections
- COVID-19 vaccine
- Booster vaccination
- Booster dose
- Vaccine effectiveness
