Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network

Joshua Hutchings; Viktoriya G. Stancheva; Nick R. Brown; Alan C. M. Cheung; Elizabeth A. Miller; Giulia Zanetti

doi:10.1038/s41467-021-22110-6

Nature Communications (Apr 2021)

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network

Joshua Hutchings,
Viktoriya G. Stancheva,
Nick R. Brown,
Alan C. M. Cheung,
Elizabeth A. Miller,
Giulia Zanetti

Affiliations

Joshua Hutchings: Institute of Structural and Molecular Biology, Birkbeck College
Viktoriya G. Stancheva: MRC Laboratory of Molecular Biology
Nick R. Brown: Institute of Structural and Molecular Biology, Birkbeck College
Alan C. M. Cheung: Institute of Structural and Molecular Biology, Birkbeck College
Elizabeth A. Miller: MRC Laboratory of Molecular Biology
Giulia Zanetti: Institute of Structural and Molecular Biology, Birkbeck College

DOI: https://doi.org/10.1038/s41467-021-22110-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Cytosolic coat proteins capture secretory cargo and sculpt membrane carriers for intracellular transport, such as COPII which mediates Endoplasmic Reticulum to Golgi trafficking of thousands of cargoes. Here authors visualise the complete, membrane-assembled COPII coat by cryo-electron tomography and subtomogram averaging, revealing the full network of interactions within and between coat layers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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