Nature Communications (Apr 2021)

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network

  • Joshua Hutchings,
  • Viktoriya G. Stancheva,
  • Nick R. Brown,
  • Alan C. M. Cheung,
  • Elizabeth A. Miller,
  • Giulia Zanetti

DOI
https://doi.org/10.1038/s41467-021-22110-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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Cytosolic coat proteins capture secretory cargo and sculpt membrane carriers for intracellular transport, such as COPII which mediates Endoplasmic Reticulum to Golgi trafficking of thousands of cargoes. Here authors visualise the complete, membrane-assembled COPII coat by cryo-electron tomography and subtomogram averaging, revealing the full network of interactions within and between coat layers.