A novel and practical asymmetric synthesis of dapoxetine hydrochloride

Yijun Zhu; Zhenren Liu; Hongyan Li; Deyong Ye; Weicheng Zhou

doi:10.3762/bjoc.11.283

Beilstein Journal of Organic Chemistry (Dec 2015)

A novel and practical asymmetric synthesis of dapoxetine hydrochloride

Yijun Zhu,
Zhenren Liu,
Hongyan Li,
Deyong Ye,
Weicheng Zhou

Affiliations

Yijun Zhu: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China
Zhenren Liu: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China
Hongyan Li: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China
Deyong Ye: School of Pharmacy, Fudan University, No. 826, Zhangheng Rd., Shanghai 201203, China
Weicheng Zhou: State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, China

DOI: https://doi.org/10.3762/bjoc.11.283
Journal volume & issue: Vol. 11, no. 1
pp. 2641 – 2645

Abstract

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A novel and practical asymmetric synthesis of dapoxetine hydrochloride by using the chiral auxiliary (S)-tert-butanesulfinamide was explored. The synthesis was concise, mild, and easy to perform. The overall yield and stereoselectivity were excellent.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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