Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Neophytos Christodoulou; Antonia Weberling; Douglas Strathdee; Kurt I. Anderson; Paul Timpson; Magdalena Zernicka-Goetz

doi:10.1038/s41467-019-11482-5

Nature Communications (Aug 2019)

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Neophytos Christodoulou,
Antonia Weberling,
Douglas Strathdee,
Kurt I. Anderson,
Paul Timpson,
Magdalena Zernicka-Goetz

Affiliations

Neophytos Christodoulou: Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience
Antonia Weberling: Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience
Douglas Strathdee: Cancer Research UK Beatson Institute
Kurt I. Anderson: Francis Crick Institute
Paul Timpson: Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division
Magdalena Zernicka-Goetz: Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience

DOI: https://doi.org/10.1038/s41467-019-11482-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling mediated trophectoderm morphogenesis orchestrates this process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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