Nature Communications (Dec 2018)
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells
- Hedia Chagraoui,
- Maiken S. Kristiansen,
- Juan Pablo Ruiz,
- Ana Serra-Barros,
- Johanna Richter,
- Elisa Hall-Ponselé,
- Nicki Gray,
- Dominic Waithe,
- Kevin Clark,
- Philip Hublitz,
- Emmanouela Repapi,
- Georg Otto,
- Paul Sopp,
- Stephen Taylor,
- Supat Thongjuea,
- Paresh Vyas,
- Catherine Porcher
Affiliations
- Hedia Chagraoui
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Maiken S. Kristiansen
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Juan Pablo Ruiz
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Ana Serra-Barros
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Johanna Richter
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Elisa Hall-Ponselé
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Nicki Gray
- Computational Biology Research Group, University of Oxford, John Radcliffe Hospital
- Dominic Waithe
- Wolfson Imaging Centre, University of Oxford, John Radcliffe Hospital
- Kevin Clark
- FACS Facility, University of Oxford, John Radcliffe Hospital
- Philip Hublitz
- Genome Engineering Facility, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital
- Emmanouela Repapi
- Computational Biology Research Group, University of Oxford, John Radcliffe Hospital
- Georg Otto
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Paul Sopp
- FACS Facility, University of Oxford, John Radcliffe Hospital
- Stephen Taylor
- Computational Biology Research Group, University of Oxford, John Radcliffe Hospital
- Supat Thongjuea
- Computational Biology Research Group, University of Oxford, John Radcliffe Hospital
- Paresh Vyas
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- Catherine Porcher
- Medical Research Council Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital
- DOI
- https://doi.org/10.1038/s41467-018-07787-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Mechanisms that operate during embryonic development to restrict cell fate are currently under investigation. Here the authors characterise the role of SCL/TAL1 at the onset of blood specification in embryonic development using mouse EB differentiation culture as a model system.
