Trypanosoma Variant Surface Glycoprotein: A Review

Abstract

The glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host. The special structures of these glycoproteins contribute to the Trypanosoma ability to evade the host. This provides a crucial role of the pathogenesis of this parasite by enabling Trypanosoma brucei to escape from the immune responses by variant its surface glycoprotein (VSG). Hence, T. brucei can keep persistence in the bloodstream. Making it a main factor in the pathogenesis of sleeping sickness disease. Furthermore, understanding the VSG functions would offer valued aspects to beneficial targets for medication caused by Trypanosoma species. As well as it elucidates the mechanisms for vaccine development and cell signaling strategies. By understanding of VSG, jobs improve the awareness of parasite biology to reduce the burden of Trypanosoma species infections and fast-track development of both effective targeting drugs and supportive vaccines in the scientific community. This collaboration between researchers can be translated into practical explanations to mitigate these diseases towards the eradication of African trypanosomiasis on public health.

Keywords

• trypanosoma brucei
• variant surface glycoprotein
• vsg