Nature Communications (Jun 2020)

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

  • Chunqing Wang,
  • Yongmei Li,
  • Shuai Yan,
  • Hao Wang,
  • Xianfeng Shao,
  • Mingming Xiao,
  • Baicai Yang,
  • Guoxuan Qin,
  • Ruirui Kong,
  • Ruibing Chen,
  • Ning Zhang

DOI
https://doi.org/10.1038/s41467-020-16966-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Here the authors present a quantitative proteomics strategy to identify long noncoding RNA (lncRNA)-binding proteins and demonstrate its application by characterizing the lncRNA HULC (highly upregulated in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity.