Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Yi Liu; Hyon-Xhi Tan; Marios Koutsakos; Sinthujan Jegaskanda; Robyn Esterbauer; Danielle Tilmanis; Malet Aban; Katherine Kedzierska; Aeron C. Hurt; Stephen J. Kent; Adam K. Wheatley

doi:10.1038/s41467-018-08165-y

Nature Communications (Jan 2019)

Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Yi Liu,
Hyon-Xhi Tan,
Marios Koutsakos,
Sinthujan Jegaskanda,
Robyn Esterbauer,
Danielle Tilmanis,
Malet Aban,
Katherine Kedzierska,
Aeron C. Hurt,
Stephen J. Kent,
Adam K. Wheatley

Affiliations

Yi Liu: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Hyon-Xhi Tan: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Marios Koutsakos: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Sinthujan Jegaskanda: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Robyn Esterbauer: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Danielle Tilmanis: World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity
Malet Aban: World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity
Katherine Kedzierska: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Aeron C. Hurt: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Stephen J. Kent: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne
Adam K. Wheatley: Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne

DOI: https://doi.org/10.1038/s41467-018-08165-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Immune recognition of Influenza B virus (IBV) is poorly understood. Here, Liu et al. use flow cytometry to characterize IBV-specific memory B cell responses following seasonal vaccination and show that elicited cross-reactive antibodies can protect against infection, providing a platform for vaccine design.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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