JACC: Basic to Translational Science (Feb 2019)
Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis
- Heather L. Teague, PhD,
- Nevin J. Varghese, BS,
- Lam C. Tsoi, PhD,
- Amit K. Dey, MD,
- Michael S. Garshick, MD,
- Joanna I. Silverman, BA,
- Yvonne Baumer, PhD,
- Charlotte L. Harrington, BA,
- Erin Stempinski, MS,
- Youssef A. Elnabawi, BS,
- Pradeep K. Dagur, PhD,
- Kairong Cui, PhD,
- Ilker Tunc, PhD,
- Fayaz Seifuddin, MSc,
- Aditya A. Joshi, MD,
- Elena Stansky, BS,
- Monica M. Purmalek, BS,
- Justin A. Rodante, PA,
- Andrew Keel, DNP,
- Tarek Z. Aridi, BS,
- Carmelo Carmona-Rivera, PhD,
- Gregory E. Sanda, BS,
- Marcus Y. Chen, MD,
- Mehdi Pirooznia, MD, PhD,
- J. Philip McCoy, Jr., PhD,
- Joel M. Gelfand, MD,
- Keji Zhao, PhD,
- Johann E. Gudjonsson, MD, PhD,
- Martin P. Playford, PhD,
- Mariana J. Kaplan, MD,
- Jeffrey S. Berger, MD,
- Nehal N. Mehta, MD
Affiliations
- Heather L. Teague, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Nevin J. Varghese, BS
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Lam C. Tsoi, PhD
- Department of Dermatology, University of Michigan, Ann Arbor, Michigan
- Amit K. Dey, MD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Michael S. Garshick, MD
- Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York
- Joanna I. Silverman, BA
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Yvonne Baumer, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Charlotte L. Harrington, BA
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Erin Stempinski, MS
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Youssef A. Elnabawi, BS
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Pradeep K. Dagur, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Kairong Cui, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Ilker Tunc, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Fayaz Seifuddin, MSc
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Aditya A. Joshi, MD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Elena Stansky, BS
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Monica M. Purmalek, BS
- Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
- Justin A. Rodante, PA
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Andrew Keel, DNP
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Tarek Z. Aridi, BS
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Carmelo Carmona-Rivera, PhD
- Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
- Gregory E. Sanda, BS
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Marcus Y. Chen, MD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Mehdi Pirooznia, MD, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- J. Philip McCoy, Jr., PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Joel M. Gelfand, MD
- Department of Dermatology, Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Biostatics, Epidemiology, and Informatics, Perelman School of Medicine, Philadelphia, Pennsylvania
- Keji Zhao, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Johann E. Gudjonsson, MD, PhD
- Department of Dermatology, University of Michigan, Ann Arbor, Michigan
- Martin P. Playford, PhD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Mariana J. Kaplan, MD
- Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
- Jeffrey S. Berger, MD
- Department of Medicine, Division of Cardiology, New York University School of Medicine, New York, New York
- Nehal N. Mehta, MD
- National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; Address for correspondence: Dr. Nehal N. Mehta, Cardiovascular and Pulmonary Branch, NHLBI, 10 Center Drive, CRC, Room 5-5140, Bethesda, Maryland 20892.
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Summary: Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte−platelet interaction may play a crucial target for clinical intervention. Key Words: cardiovascular disease, low-density granulocytes, neutrophils, platelets, psoriasis
