Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease

Virginia Boccardi; Eric Westman; Luca Pelini; Olof Lindberg; J-Sebastian Muehlboeck; Andrew Simmons; Roberto Tarducci; Piero Floridi; Pietro Chiarini; Hilkka Soininen; Iwona Kloszewska; Magda Tsolaki; Bruno Vellas; Christian Spenger; Lars-Olof Wahlund; Simon Lovestone; Patrizia Mecocci

doi:10.3389/fnagi.2018.00439

Frontiers in Aging Neuroscience (Jan 2019)

Differential Associations of IL-4 With Hippocampal Subfields in Mild Cognitive Impairment and Alzheimer’s Disease

Virginia Boccardi,
Eric Westman,
Luca Pelini,
Olof Lindberg,
J-Sebastian Muehlboeck,
Andrew Simmons,
Roberto Tarducci,
Piero Floridi,
Pietro Chiarini,
Hilkka Soininen,
Iwona Kloszewska,
Magda Tsolaki,
Bruno Vellas,
Christian Spenger,
Lars-Olof Wahlund,
Simon Lovestone,
Patrizia Mecocci

Affiliations

Virginia Boccardi: Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
Eric Westman: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Luca Pelini: Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
Olof Lindberg: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
J-Sebastian Muehlboeck: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Andrew Simmons: Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom
Roberto Tarducci: Division of Medical Physics, Perugia University Hospital, Perugia, Italy
Piero Floridi: Division of Neuroradiology, Perugia University Hospital, Perugia, Italy
Pietro Chiarini: Division of Neuroradiology, Perugia University Hospital, Perugia, Italy
Hilkka Soininen: Department of Neurology, University of Eastern Finland – Kuopio University Hospital, Kuopio, Finland
Iwona Kloszewska: Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Łódź, Łódź, Poland
Magda Tsolaki: 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Bruno Vellas: University of Toulouse, INSERM 1027, Gérontopôle, Toulouse, France
Christian Spenger: 0Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Lars-Olof Wahlund: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Simon Lovestone: 1Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom
Patrizia Mecocci: Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy

DOI: https://doi.org/10.3389/fnagi.2018.00439
Journal volume & issue: Vol. 10

Abstract

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Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions – in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD- with circulating levels of IL-4.Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay.Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD.Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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