Marine Drugs (Dec 2018)

Antiviral and Antioxidant Properties of Echinochrome A

  • Sergey A. Fedoreyev,
  • Natalia V. Krylova,
  • Natalia P. Mishchenko,
  • Elena A. Vasileva,
  • Evgeny A. Pislyagin,
  • Olga V. Iunikhina,
  • Vyacheslav F. Lavrov,
  • Oksana A. Svitich,
  • Linna K. Ebralidze,
  • Galina N. Leonova

DOI
https://doi.org/10.3390/md16120509
Journal volume & issue
Vol. 16, no. 12
p. 509

Abstract

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The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and α-tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.

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