Risk Assessment of Nephrotoxic Metals in Soil and Water in Areas with High Prevalence of Chronic Kidney Disease in Panama

Abstract

Mesoamerican nephropathy (MeN) is a non-traditional chronic kidney disease in some areas of Mesoamerica. The health risk from nephrotoxic metals, such as arsenic (As), lead (Pb), mercury (Hg), vanadium (V), cadmium (Cd), rubidium (Rb), chromium (Cr), and nickel (Ni), was assessed in drinking water and soils. These metals, even at low concentrations, have the capacity to induce epigenetic damage and a nephrotoxic effect. The quantification of metals in soils was made through X-ray fluorescence spectrometry (XRF) and inductively coupled plasma optical emission spectrophotometry (ICP-OES), while the quantification of metals in water was carried out through inductively coupled plasma mass spectrometry (ICPMS) and atomic absorption (AA) spectrometry. The levels of As, Hg, Cd, and V in water were within the permissible limits, whereas Pb was found to be double and triple the value recommended by the World Health Organization. The non-carcinogenic risk from As in soil was evaluated using the Hazard Index (HI), and the route of ingestion was found to be the most important route. The results indicate that consuming water or ingesting soil particles with Pb and As poses a health risk to humans. Therefore, these findings identify the presence of toxicants in an exposure scenario and justify further research into these metals in people and the analysis of exposure routes.

Keywords

• non-traditional chronic kidney disease
• heavy metals
• toxicity
• accidental geophagy
• exposure route